This is what I do:
- use a little bigger resolution
XFdrake

- use 100dpi fonts
/etc/X11/fs/config
default-resolutions = 100,100,75,75

- increase minimal font size in Konqueror a lot

- use Lucidatypewriter as monospace font in KDE

- use Unicode font in Konsole

- in Openoffice.org replace Andale Sans UI with Helvetica:
http://www.openoffice.org/FAQs/fontguide.html#8